Objective To explore the application effect of the chemotherapy-induced nausea and vomiting (CINV) standardized model ward ("vomit-free ward") management mode in patients with malignant tumors undergoing chemotherapy. Methods A before-and-after controlled study design was adopted. A total of 98 chemotherapy patients admitted from January to June 2023 (before the implementation of the "vomit-free ward" management mode) were selected as the control group, and they were given conventional antiemetic measures. A total of 91 chemotherapy patients admitted from January to June 2024 (after the implementation of the "vomit-free ward" management mode) were selected as the observation group, and the "vomit-free ward" management mode was implemented. The incidence and severity of CINV, chemotherapy compliance, satisfaction, and quality of life were compared between the two groups. Results The incidence rates of nausea (32.97% vs. 55.10%) and vomiting (25.27% vs. 48.98%) in the observation group were lower than those in the control group (all P<0.05); the severity of nausea and vomiting in the observation group were lower than those in the control group (all P<0.05); the distribution of chemotherapy compliance, satisfaction, and quality of life grades in the observation group were better than those in the control group (all P<0.05). Conclusion The application of the "nvomit-fre ward" management mode can effectively reduce the incidence and severity of CINV in patients with malignant tumors undergoing chemotherapy, and significantly improve patients' treatment compliance, satisfaction, and quality of life. This multidisciplinary collaborative management mode has clinical promotion value.

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